Kelly Preston starring in ABC comedy pilot 'Keep Calm and Karey On'

Kelly Preston is returning to the world of series TV with the lead role in ABC's comedy pilot "Keep Calm and Karey On."

Preston will star as Karey, the straight arrow in a family of petty thieves, drug addicts and narcissists. When her brother is sent to prison, she adopts his two children in an attempt to give them a better life.

The cast also includes Jane Seymour ("Dr. Quinn, Medicine Woman") as Karey's mother and Majandra Delfino ("Roswell") as Karey's self-absorbed sister. Andrea Abbate ("Accidentally on Purpose") wrote the script.

If the pilot is picked up to series, it would mark Preston's first full-time TV commitment since her role as an oversexed teenager in NBC's short-lived '80s Army base soap "For Love and Honor." She was in the cast of HBO's 2008 pilot for British TV adaptation "Suburban Shootout," but that was not picked up.

Preston is best known for feature films including "Jerry Maguire," "The Last Song" and "Twins," as well as her 22 year marriage to John Travolta. Her TV guest work includes stints on "Medium," "Joey," "Fat Actress," "CHiPs" and the original "Hawaii Five-O."