'The Simpsons': Jennifer Tilly to guest star? Bet on it

This is a pairing we never thought we'd see. Actress/poker player Jennifer Tilly has signed on to guest in an upcoming episode of "The Simpsons."

EW is reporting that Tilly, the ex-wife of show EP Sam Simon, will play herself on the long-running animated comedy. In the episode, Homer doesn't trust the Bank of Springfield, so he deposits Lisa's college fund in an online poker site. Tilly is introduced as part of an instructional poker DVD Lisa watches. What are the chances some of this money will be gambled away?

EP Al Jean says, "It was a real pleasure to have the Bride of Chucky on the show. Only three people in the crew were mysteriously killed."

Tilly is no stranger to working in cartoons. She's a frequent contributor to "Family Guy" as Bonnie Swanson, and she also played Celia in the movie "Monsters, Inc."

The episode featuring Tilly will air early next season.