WATCH: Kelsey Grammer is the 'Boss' in new Starz series

In "Boss," his first dramatic television series, Kelsey Grammer ("Frazier") plays Mayor Tom Kane, who sits at the center of Chicago politics and -- one way or another -- keeps his voter base happy. He's also hiding the fact that he's got a degenerative disorder that is slowly chipping away at his brain. This could get interesting.

In the 12-minute clip above -- that includes some interesting behind-the-scenes history -- we learn a little bit about Tom Kane; what makes him tick. We also meet his wife Meredith (Connie Nielsen), who is in it strictly for the image. Advisers Kitty O'Neil (Kathleen Robertson) and Ezra Stone (Martin Donovan) don't really have any idea what's going on, but Kane's estranged daughter, played by Hannah Ware, may have a clue.

"Boss," a Starz original series, debuts on Friday, Oct. 21 at 10 p.m. ET.